An mRNA vaccine candidate encoding H5HA clade 2.3.4.4b protects mice from clade 2.3.2.1a virus infection

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2024年10月14日

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Shiho Chiba,
Maki Kiso,
Shinya Yamada,
Kazuhiko Someya,
Yoshikuni Onodera,
Aya Yamaguchi,
Satoko Matsunaga,
Ryuta Uraki,
Kiyoko Iwatsuki-Horimoto,
Seiya Yamayoshi,
Fumihiko Takeshita,
Yoshihiro Kawaoka

摘要

Highly pathogenic avian influenza (HPAI) H5 viruses from different clades have been circulating globally, threatening wild/domestic birds and mammals. Given frequent spillovers and high mortality among mammals, coupled with our inability to predict which clade of H5 virus has pandemic potential, cross-clade protective HPAI H5 vaccines are urgently needed. Here, we demonstrate the applicability of a lipid nanoparticle-based mRNA vaccine modality to induce cross-protective immunity against lethal HPAI virus infection.