Scholarlink

<p>Here, we review mathematical models of epigenetic memory, focusing on chromatin modifications as key mechanisms to achieve long-term maintenance of epigenetic states. After reviewing the main stochastic modeling frameworks, we focus on stochastic models of chromatin modifications to analyze residence time in memory states, which underpins the long-term maintenance of epigenetic information. We review these concepts through increasingly complicated chromatin modification circuits, including histone modifications, DNA methylation, and their combination.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Stochastic modeling of epigenetic memory

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月11日

查看全文
  • Simone Bruno,
  • Domitilla Del Vecchio

摘要

Here, we review mathematical models of epigenetic memory, focusing on chromatin modifications as key mechanisms to achieve long-term maintenance of epigenetic states. After reviewing the main stochastic modeling frameworks, we focus on stochastic models of chromatin modifications to analyze residence time in memory states, which underpins the long-term maintenance of epigenetic information. We review these concepts through increasingly complicated chromatin modification circuits, including histone modifications, DNA methylation, and their combination.