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<p>Digital twins (DTs) can transform randomized clinical trials by improving ethical standards, including safety, informed consent, equity, and data privacy. They also enhance trial efficiency by enabling early detection of adverse events and streamlined design. This paper explores the role of DTs in personalized medicine, from pre-clinical research to post-marketing, while addressing technological, legal, and ethical challenges in implementation.</p>

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Enhancing randomized clinical trials with digital twins

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月3日

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  • Hossein Akbarialiabad,
  • Amirmohammad Pasdar,
  • Dédée F. Murrell,
  • Mehrnaz Mostafavi,
  • Farhan Shakil,
  • Ehsan Safaee,
  • Sancy A. Leachman,
  • Alireza Haghighi,
  • Michelle Tarbox,
  • Christopher G. Bunick,
  • Ayman Grada

摘要

Digital twins (DTs) can transform randomized clinical trials by improving ethical standards, including safety, informed consent, equity, and data privacy. They also enhance trial efficiency by enabling early detection of adverse events and streamlined design. This paper explores the role of DTs in personalized medicine, from pre-clinical research to post-marketing, while addressing technological, legal, and ethical challenges in implementation.