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<p>Conventional dietary indices often fail to align with aging biology. To bridge this mechanistic gap, we propose the Nutrient–Signaling–Senescence (NSS) axis as an integrative framework. Based on this foundation, we develop the anti-aging dietary score (AADS). Preliminary validation using NHANES data demonstrates that a higher AADS is significantly associated with lower PhenoAge acceleration, performing comparably to established indices. This framework enables translating aging biology into population-based research.</p>

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Reframing diet assessment for geroscience: development and preliminary validation of an anti-aging dietary score

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月22日

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  • Shixing Feng,
  • Tianyi Wang,
  • Jinlong Yan,
  • Chaohui Yin,
  • Baoyan Chen,
  • Miao Shi,
  • Jialin Liu,
  • Huaqiang Zhai

摘要

Conventional dietary indices often fail to align with aging biology. To bridge this mechanistic gap, we propose the Nutrient–Signaling–Senescence (NSS) axis as an integrative framework. Based on this foundation, we develop the anti-aging dietary score (AADS). Preliminary validation using NHANES data demonstrates that a higher AADS is significantly associated with lower PhenoAge acceleration, performing comparably to established indices. This framework enables translating aging biology into population-based research.