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<p>L-citrulline (L-Cit) has emerged as a potential supplement to enhance muscle performance and protein metabolism. This review summarizes evidence from rodent and human studies, highlighting its effects on muscle function, protein synthesis, and underlying mechanisms. Key areas for future research include supplementation strategies, transport and metabolism pathways, mitochondrial function, and the interaction between L-Cit, gut microbiota, and muscle health, offering insights for nutritional interventions targeting aging and sarcopenia.</p>

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Potential role of L-citrulline in regulating exercise performance and muscle protein metabolism

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月18日

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  • Xiaokang Lv,
  • Yating Song,
  • Tian Guo,
  • Jinling Hua

摘要

L-citrulline (L-Cit) has emerged as a potential supplement to enhance muscle performance and protein metabolism. This review summarizes evidence from rodent and human studies, highlighting its effects on muscle function, protein synthesis, and underlying mechanisms. Key areas for future research include supplementation strategies, transport and metabolism pathways, mitochondrial function, and the interaction between L-Cit, gut microbiota, and muscle health, offering insights for nutritional interventions targeting aging and sarcopenia.