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<p>Antarctic krill oil (KO) is a richsource of omega-3 polyunsaturated fatty acids (PUFAs). Endogenous PUFA-derived specialized pro-resolving mediators (SPMs) have garnered attention due to their beneficial effects on body, especially the cardiovascular system. This study integrated non-targeted and targeted lipidomics to investigate KO’s time-dependent effects on the comprehensive lipid profile and SPMs in rats. After 1- and 6-week supplementation, KO significantly altered lipid profiles, reducing arachidonic acid (ARA, 20:4)-containing lipids while elevating eicosapentaenoic acid (EPA, 20:5)/docosahexaenoic acid (DHA, 22:6)-containing lipids. Targeted analysis identified and quantified 33 PUFA-derived oxylipins, including derivatives of ARA, 8 derivatives of EPA, and 13 derivatives of DHA. Notably, KO consumption substantially decreased pro-inflammatory oxylipins like LTB<sub>4</sub>, PGE<sub>2</sub>, and TXB<sub>2</sub>, while increasing anti-inflammatory LXA<sub>4</sub> and SPMs such as RvE1, RvE2, RvD1, RvD4, and MaR1. Long-term intake amplified SPM accumulation, suggesting temporal regulation. These findings elucidate KO’s potential mechanism in inflammation management through lipidome remodeling, supporting its application in functional foods for metabolic health enhancement.</p>

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Effects of Antarctic krill oil on lipid profiles and SPM levels in rats over time

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月10日

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  • Weibo Lu,
  • Ning Huangfu,
  • Lijun Ge,
  • Huixiang Wu,
  • Shitong Wang,
  • Jiahui Wu,
  • Jing Xue,
  • Chunlai Zeng,
  • Tianming Xuan,
  • Liqun Cui,
  • Jianliang Zhang,
  • Linhua Wang,
  • Qingcheng Wang,
  • Jie Yuan,
  • Hongqiang Wang,
  • Hong Yuan,
  • Xinghua Bai,
  • Huamin Yu,
  • Xi Chen,
  • Qing Shen,
  • Keyun Cheng

摘要

Antarctic krill oil (KO) is a richsource of omega-3 polyunsaturated fatty acids (PUFAs). Endogenous PUFA-derived specialized pro-resolving mediators (SPMs) have garnered attention due to their beneficial effects on body, especially the cardiovascular system. This study integrated non-targeted and targeted lipidomics to investigate KO’s time-dependent effects on the comprehensive lipid profile and SPMs in rats. After 1- and 6-week supplementation, KO significantly altered lipid profiles, reducing arachidonic acid (ARA, 20:4)-containing lipids while elevating eicosapentaenoic acid (EPA, 20:5)/docosahexaenoic acid (DHA, 22:6)-containing lipids. Targeted analysis identified and quantified 33 PUFA-derived oxylipins, including derivatives of ARA, 8 derivatives of EPA, and 13 derivatives of DHA. Notably, KO consumption substantially decreased pro-inflammatory oxylipins like LTB4, PGE2, and TXB2, while increasing anti-inflammatory LXA4 and SPMs such as RvE1, RvE2, RvD1, RvD4, and MaR1. Long-term intake amplified SPM accumulation, suggesting temporal regulation. These findings elucidate KO’s potential mechanism in inflammation management through lipidome remodeling, supporting its application in functional foods for metabolic health enhancement.