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<p>Iron deficiency anemia (IDA) is a prevalent nutritional disorder primarily treated with inorganic iron supplements. However, these interventions are often limited by poor bioavailability and gastrointestinal side effects. Food-derived protein hydrolysates have emerged as promising dietary strategies to enhance iron absorption and mitigate adverse effects. This study evaluated the efficacy of dietary supplementation with Donkey-hide gelatin hydrolysates (DH) in alleviating IDA in a rat model. DH-Fe exhibited superior binding affinity and stability, retaining more soluble iron fraction under diverse conditions, confirming its role as a functional dietary iron carrier. In vivo, DH markedly enhanced hematopoiesis and iron homeostasis, elevating hemoglobin by 44% and normalizing serum ferritin (25.34 ng/mL). DH also enhanced antioxidant defenses, increasing SOD and hydroxyproline levels to 111% and 168% of the reference groups, respectively. Moreover, DH ameliorated IDA-induced liver injury and gut microbiota dysbiosis by promoting beneficial bacteria (e.g., <i>Ruminococcus</i>) and suppressing pathogenic bacteria (e.g., <i>Escherichia-Shigella</i>). Overall, these findings indicate that DH improves hematopoiesis and modulates gut microbiota composition, supporting its potential as a next-generation dietary iron supplement for IDA management.</p><p></p>

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Stability and iron affinity of Donkey-hide gelatin hydrolysates: Implications for improving iron bioavailability and gut microbiota modulation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月26日

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  • Hao-Bin Lin,
  • Chun-Yan Peng,
  • Hui Wang,
  • Yang-En Sun,
  • Xiao-Bo Duan,
  • Hai-Bin Liu,
  • Xin-Yi Lin,
  • Le-Ying Yang,
  • Zong-Cai Tu,
  • Xiao-Mei Sha

摘要

Iron deficiency anemia (IDA) is a prevalent nutritional disorder primarily treated with inorganic iron supplements. However, these interventions are often limited by poor bioavailability and gastrointestinal side effects. Food-derived protein hydrolysates have emerged as promising dietary strategies to enhance iron absorption and mitigate adverse effects. This study evaluated the efficacy of dietary supplementation with Donkey-hide gelatin hydrolysates (DH) in alleviating IDA in a rat model. DH-Fe exhibited superior binding affinity and stability, retaining more soluble iron fraction under diverse conditions, confirming its role as a functional dietary iron carrier. In vivo, DH markedly enhanced hematopoiesis and iron homeostasis, elevating hemoglobin by 44% and normalizing serum ferritin (25.34 ng/mL). DH also enhanced antioxidant defenses, increasing SOD and hydroxyproline levels to 111% and 168% of the reference groups, respectively. Moreover, DH ameliorated IDA-induced liver injury and gut microbiota dysbiosis by promoting beneficial bacteria (e.g., Ruminococcus) and suppressing pathogenic bacteria (e.g., Escherichia-Shigella). Overall, these findings indicate that DH improves hematopoiesis and modulates gut microbiota composition, supporting its potential as a next-generation dietary iron supplement for IDA management.