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<p>Cancer-related fatigue (CRF) is a common symptom in cancer patients, affecting their quality of life. <i>Prunella vulgaris</i> and its seed oil (PVSO) are edible-medicinal foods with bioactive compounds that may alleviate CRF. The present study aimed to test the effects of PVSO on CRF and underlying mechanisms. We found PVSO improved fatigue-like behaviors in both LPS-induced and tumor-bearing models. In the breast cancer tumor-bearing animals, PVSO reduced tumor growth, and suppressed serum and hypothalamic inflammatory cytokines (<i>TNF-α, IL-1β</i>, and <i>IL-6</i>) and NF-κB signaling. Furthermore, the hypothalamic corticotropin-releasing hormone (CRH) expression and serum CRH/cortisol levels dampened in tumor-bearing animals were normalized by PVSO. Our results suggest that PVSO exhibits potent anti-CRF effects likely via attenuation of cancer-induced hypothalamic inflammation and subsequent normalization of the dysregulated HPA axis. PVSO may be developed as a functional food for breast cancer-related fatigue.</p>

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Prunella vulgaris seed oil alleviates cancer related fatigue through hypothalamic inflammation and CRH regulation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月24日

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  • Changyu Wu,
  • Qing Hu,
  • Mingzhi Han,
  • Yuhan Peng,
  • Chengyu Zhang,
  • Zhangjie Wu,
  • Ruiyi Liu,
  • Shan Xing,
  • Ying Yin,
  • Mária A. Deli,
  • Hailou Zhang,
  • Gang Chen

摘要

Cancer-related fatigue (CRF) is a common symptom in cancer patients, affecting their quality of life. Prunella vulgaris and its seed oil (PVSO) are edible-medicinal foods with bioactive compounds that may alleviate CRF. The present study aimed to test the effects of PVSO on CRF and underlying mechanisms. We found PVSO improved fatigue-like behaviors in both LPS-induced and tumor-bearing models. In the breast cancer tumor-bearing animals, PVSO reduced tumor growth, and suppressed serum and hypothalamic inflammatory cytokines (TNF-α, IL-1β, and IL-6) and NF-κB signaling. Furthermore, the hypothalamic corticotropin-releasing hormone (CRH) expression and serum CRH/cortisol levels dampened in tumor-bearing animals were normalized by PVSO. Our results suggest that PVSO exhibits potent anti-CRF effects likely via attenuation of cancer-induced hypothalamic inflammation and subsequent normalization of the dysregulated HPA axis. PVSO may be developed as a functional food for breast cancer-related fatigue.