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<p>Chronic inflammation plays a significant role in the development and progression of metabolic dysfunction-related diseases. This study investigating a protein hydrolysate from <i>Lupinus angustifolius</i> (LPH) in mice model on a western diet (WD) aimed to elucidate its potential beneficial role in improving the lipidomic and anti-inflammatory profile. To achieve this objective, a lipidomic approach in combination with the evaluation of protein level modulation of selected key enzymes that are pivotal involved in the bioactive lipid pathway synthesis/regulation was performed on liver homogenates. Specifically, LPH positively impacted DHCer, SM, LacCer, Sph 1, DHSph 1, and S1P 1 concentrations, and restored the basal conditions of ASAH1 and ASM, proteins involved in sphingolipid metabolism. LPH also reduced the FASN and PPARγ levels and eicosanoids, with positive modulation of the COX-2 and ALOX5. Additionally, LPH reduced the WB-induced AEA and 2AG concentrations.</p>

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Integratomic investigation to assess the liver lipidomic and antiinflammatory activity of lupin protein hydrolysate

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月28日

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  • Sara Casati,
  • Michele Dei Cas,
  • Lorenza d’Adduzio,
  • Ivan Cruz-Chamorro,
  • Guillermo Santos- Sánchez,
  • Carlotta Bollati,
  • Melissa Fanzaga,
  • Justo Pedroche,
  • María del Carmen Millán-Linares,
  • Gabriella Roda,
  • Antonio Carrillo-Vico,
  • Carmen Lammi

摘要

Chronic inflammation plays a significant role in the development and progression of metabolic dysfunction-related diseases. This study investigating a protein hydrolysate from Lupinus angustifolius (LPH) in mice model on a western diet (WD) aimed to elucidate its potential beneficial role in improving the lipidomic and anti-inflammatory profile. To achieve this objective, a lipidomic approach in combination with the evaluation of protein level modulation of selected key enzymes that are pivotal involved in the bioactive lipid pathway synthesis/regulation was performed on liver homogenates. Specifically, LPH positively impacted DHCer, SM, LacCer, Sph 1, DHSph 1, and S1P 1 concentrations, and restored the basal conditions of ASAH1 and ASM, proteins involved in sphingolipid metabolism. LPH also reduced the FASN and PPARγ levels and eicosanoids, with positive modulation of the COX-2 and ALOX5. Additionally, LPH reduced the WB-induced AEA and 2AG concentrations.