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<p>Background: Schizophrenia is a severe mental disorder with significant impact on quality of life (QoL). Reliable measurement of QoL is essential for evaluating treatment outcomes. Methods: We applied the COSMIN (COnsensus-based Standards for the selection of health Measurement INstruments) systematic review guideline to evaluate the psychometric properties of Lehman’s Quality of Life Interview (QOLI), the Lancashire Quality of Life Profile (LQOLP), and the Manchester Short Assessment of Quality of Life (MANSA) as patient-reported outcome measures (PROMs). Results: The combined search of PubMed and EMBASE yielded 19 included studies: 4 for QOLI, 10 for LQOLP, and 4 for MANSA. The overall results of the measurement properties across all three scales are largely insufficient or indeterminate. Evidence for several measurement properties is missing for the individual scales, with studies on content validity in particular being absent for all three scales. Conclusion: All three scales fall in COSMIN category B, meaning they have potential to be recommended but certain important evidence for recommendation is missing. However, newer scales - such as the Schizophrenia Quality of Life Scale - have been developed using more modern approaches. Consequently, prioritizing the further evaluation of these newer instruments may prove more productive than continued research into older scales.</p>

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Psychometric properties of Lehman’s quality of life interview and its modifications: a systematic review using the COSMIN methodology

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月23日

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  • Max Wiessner,
  • Milena Zúñiga Le-Bert,
  • Sophia Wehr,
  • Lucia Weigel,
  • Stefan Leucht

摘要

Background: Schizophrenia is a severe mental disorder with significant impact on quality of life (QoL). Reliable measurement of QoL is essential for evaluating treatment outcomes. Methods: We applied the COSMIN (COnsensus-based Standards for the selection of health Measurement INstruments) systematic review guideline to evaluate the psychometric properties of Lehman’s Quality of Life Interview (QOLI), the Lancashire Quality of Life Profile (LQOLP), and the Manchester Short Assessment of Quality of Life (MANSA) as patient-reported outcome measures (PROMs). Results: The combined search of PubMed and EMBASE yielded 19 included studies: 4 for QOLI, 10 for LQOLP, and 4 for MANSA. The overall results of the measurement properties across all three scales are largely insufficient or indeterminate. Evidence for several measurement properties is missing for the individual scales, with studies on content validity in particular being absent for all three scales. Conclusion: All three scales fall in COSMIN category B, meaning they have potential to be recommended but certain important evidence for recommendation is missing. However, newer scales - such as the Schizophrenia Quality of Life Scale - have been developed using more modern approaches. Consequently, prioritizing the further evaluation of these newer instruments may prove more productive than continued research into older scales.