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<p>We aimed to examine the association between gut permeability biomarkers (LBP, sCD14) and insulin resistance (IR) in schizophrenia. In this cross-sectional study of 91 patients, IR (HOMA-IR ≥ 3.0) was associated with higher LBP, C-reactive protein, body mass index (BMI), and lower physical activity. Logistic regression identified LBP and BMI as independent risk factors, whereas physical activity was protective. These findings suggest altered gut permeability could influence glucose metabolism dysfunction in schizophrenia.</p>

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Insulin resistance in patients with schizophrenia: is it related to gut permeability?

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月27日

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  • Manuel Couce-Sánchez,
  • Francesco Dal Santo,
  • Leticia González-Blanco,
  • Gonzalo Paniagua,
  • Julia Rodríguez-Revuelta,
  • Pilar A. Sáiz,
  • M. Paz García-Portilla

摘要

We aimed to examine the association between gut permeability biomarkers (LBP, sCD14) and insulin resistance (IR) in schizophrenia. In this cross-sectional study of 91 patients, IR (HOMA-IR ≥ 3.0) was associated with higher LBP, C-reactive protein, body mass index (BMI), and lower physical activity. Logistic regression identified LBP and BMI as independent risk factors, whereas physical activity was protective. These findings suggest altered gut permeability could influence glucose metabolism dysfunction in schizophrenia.