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<p>In this proof of concept study, we demonstrated how Large Language Models (LLMs) can automate the conversion of unstructured case reports into clinical ratings. By leveraging instructions from a standardized clinical rating scale and evaluating the LLM’s confidence in its outputs, we aimed to refine prompting strategies and enhance reproducibility. Using this strategy and case reports of drug-induced Parkinsonism, we showed that LLM-extracted data closely align with clinical rater manual extraction, achieving an accuracy of 90%.</p>

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Validating large language models against manual information extraction from case reports of drug-induced parkinsonism in patients with schizophrenia spectrum and mood disorders: a proof of concept study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年3月20日

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  • Sebastian Volkmer,
  • Alina Glück,
  • Andreas Meyer-Lindenberg,
  • Emanuel Schwarz,
  • Dusan Hirjak

摘要

In this proof of concept study, we demonstrated how Large Language Models (LLMs) can automate the conversion of unstructured case reports into clinical ratings. By leveraging instructions from a standardized clinical rating scale and evaluating the LLM’s confidence in its outputs, we aimed to refine prompting strategies and enhance reproducibility. Using this strategy and case reports of drug-induced Parkinsonism, we showed that LLM-extracted data closely align with clinical rater manual extraction, achieving an accuracy of 90%.