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<p>Pancreatic β-cell dysfunction causes diabetes in over 400 million worldwide. Islet transplantation promises but faces donor scarcity, rejection, and hypoxic failure. β cells are vulnerable to oxygen deprivation, affecting survival and function. Strategies include pre-implantation, prevascularization, genetic modifications to improve survival; biomaterial encapsulation for immune protection and nutrients; and oxygen delivery after implantation to sustain viability, advancing islet transplantation for diabetes.</p>

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Engineering the oxygen microenvironment for pancreatic islet transplants

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月20日

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  • Samantha Kruzshak,
  • Flannery G. Williams,
  • Gulden Camci-Unal,
  • Emmanuel S. Tzanakakis

摘要

Pancreatic β-cell dysfunction causes diabetes in over 400 million worldwide. Islet transplantation promises but faces donor scarcity, rejection, and hypoxic failure. β cells are vulnerable to oxygen deprivation, affecting survival and function. Strategies include pre-implantation, prevascularization, genetic modifications to improve survival; biomaterial encapsulation for immune protection and nutrients; and oxygen delivery after implantation to sustain viability, advancing islet transplantation for diabetes.