<p>Mitigating noise-induced decoherence is the central challenge in controlling open quantum systems. While existing robust protocols often require precise noise models, we introduce a universal framework for noise-agnostic quantum control that achieves high-fidelity operations without prior environmental noise characterization. This framework capitalizes on the dynamical modification of the system-environment coupling through control drives, an effect rigorously encoded in the dynamical equation. Since the derived noise sensitivity metric remains independent of the coupling details between the system and the environment, our protocol demonstrates robustness against arbitrary Markovian noises within the first-order weak coupling approximation. Numerical validation through quantum state transfer and gate operations reveals near-unity fidelity across diverse noise regimes, achieving orders-of-magnitude error suppression compared to target-only approaches. This framework bridges critical gaps between theoretical control design and experimental constraints, establishing a broadly applicable strategy for high-fidelity quantum information processing across platforms such as superconducting circuits, trapped ions, and solid-state qubits.</p>