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<p>The aim was to evaluate the diagnostic accuracy of lung function measurements for asthma in primary care, including trial treatment. Undiagnosed patients seeking care for asthma-like symptoms were assessed at primary healthcare centers in Sweden. Participants underwent remote or in-clinic spirometry with bronchodilator responsiveness testing (BDR), remote diurnal variability testing of forced expiratory volume in 1 s (FEV<sub>1</sub>) and peak expiratory flow (PEF) over 2–4 weeks using a home spirometry system; and if necessary, three-months trial treatment with inhaled corticosteroids. Overall, 71/123 (58%) were diagnosed with asthma. When comparing patients by asthma diagnosis, sensitivity and specificity for documented diagnosis were 9% (95% CI 3–17) and 100% (93–100) for BDR; 61% (48–72) and 58% (43–71) for FEV₁; and 76% (64–85) and 69% (55–81) for PEF. Diurnal variability testing via home spirometry showed the strongest balance among sensitivity and specificity for asthma.</p>

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Assessing diagnostic accuracy for asthma with home spirometry in primary care

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月26日

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  • Lynnea Myers,
  • Martin Bellander,
  • Henrik Ljungberg,
  • Martine Isachsen,
  • Marianne Eduards,
  • Marie Lindman,
  • Anna Carleborg,
  • Maria Rosengren,
  • Magnus Jansson,
  • Hanna Sandelowsky,
  • Kjell Larsson,
  • Björn Nordlund

摘要

The aim was to evaluate the diagnostic accuracy of lung function measurements for asthma in primary care, including trial treatment. Undiagnosed patients seeking care for asthma-like symptoms were assessed at primary healthcare centers in Sweden. Participants underwent remote or in-clinic spirometry with bronchodilator responsiveness testing (BDR), remote diurnal variability testing of forced expiratory volume in 1 s (FEV1) and peak expiratory flow (PEF) over 2–4 weeks using a home spirometry system; and if necessary, three-months trial treatment with inhaled corticosteroids. Overall, 71/123 (58%) were diagnosed with asthma. When comparing patients by asthma diagnosis, sensitivity and specificity for documented diagnosis were 9% (95% CI 3–17) and 100% (93–100) for BDR; 61% (48–72) and 58% (43–71) for FEV₁; and 76% (64–85) and 69% (55–81) for PEF. Diurnal variability testing via home spirometry showed the strongest balance among sensitivity and specificity for asthma.