<p>Olfactory decline is an early sign of Parkinson’s disease (PD), often preceding motor symptoms by years to decades. However, because olfactory impairment is also common in healthy and diseased aging, current olfactory performance tests (odor detection, discrimination, and identification) lack disease specificity. In contrast to performance scores, odor-rating-derived olfactory perceptual fingerprints provide a stable measure of how the world smells to an individual. Here, we combine such fingerprints with odor-evoked sniff-response behavior to define an olfactory perceptual-motor signature. To test the hypothesis that this provides a disease-specific marker, we obtained such signatures in three cohorts: Individuals with PD (<i>n</i> = 33), healthy age-matched controls (<i>n</i> = 33), and critically, in participants with non-PD olfactory dysfunction (<i>n</i> = 28). Consistent with previous results, a standard clinical olfactory test detected impairment in both PD and non-PD olfactory dysfunction, but failed to distinguish between these two groups. In contrast, the olfactory perceptual-motor signature both detected impairment and classified PD from non-PD olfactory dysfunction at 94% accuracy (SVM classification, leave-one-out cross-validation, 100% sensitivity, 88% specificity, <i>P</i> = 0.0047). These results dovetail with evidence from vision and audition, implying a perceptual shift rather than only a perceptual decline in PD, and point to the olfactory perceptual-motor signature as a possible disease-specific marker.</p>