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<p>Parkinson’s disease (PD) patients undergo deep brain stimulation (DBS) when other treatments are insufficient. Given the patients’ advanced clinical stage, an advanced neuropathological stage is assumed. We examined Lewy pathology in prefrontal cortices (PFCs) of DBS recipients. Virtually no Lewy pathology was seen in PD biopsies. In contrast, postmortem PD PFC samples showed significantly greater Lewy pathology than controls. Thus, DBS patients may be less neuropathologically advanced in progression than previously thought.</p>

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Lewy pathology largely absent in prefrontal cortices of Parkinson’s disease patients undergoing deep brain stimulation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月1日

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  • Ariela S. Buxbaum Grice,
  • Brian H. Kopell,
  • Klaudia F. Laborc,
  • Anina N. Lund,
  • Renata Gonzalez Chong,
  • Meredith Spadaccia,
  • Gerard Ona,
  • Girish Nadkarni,
  • John F. Crary,
  • Alexander W. Charney,
  • Noam D. Beckmann

摘要

Parkinson’s disease (PD) patients undergo deep brain stimulation (DBS) when other treatments are insufficient. Given the patients’ advanced clinical stage, an advanced neuropathological stage is assumed. We examined Lewy pathology in prefrontal cortices (PFCs) of DBS recipients. Virtually no Lewy pathology was seen in PD biopsies. In contrast, postmortem PD PFC samples showed significantly greater Lewy pathology than controls. Thus, DBS patients may be less neuropathologically advanced in progression than previously thought.