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<p>Isolated/idiopathic rapid-eye movement (REM) sleep behavior disorder (iRBD) is, in most cases, an early form of α -synuclein-related neurodegenerative diseases, including Parkinson’s disease and dementia with Lewy bodies. Clinical reports suggest that iRBD is more common in individuals with Post-Traumatic Stress Disorder (PTSD) compared to those without PTSD. We conducted polygenic risk score (PRS), genetic correlation, and Mendelian randomization analyses to explore potential genetic and/or causal associations between PTSD and iRBD. Dopamine transporter imaging binding status was also examined in iRBD patients with (<i>N</i> = 6) and without PTSD (<i>N</i> = 32). While not supporting a causal relationship, genetic analyses revealed a significant association between PTSD and iRBD, consistent with the exploratory imaging substudy. These findings suggest that individuals genetically at risk for PTSD may also be at higher risk for iRBD. Further investigation of iRBD in individuals with PTSD may help inform potential neurodegenerative risk.</p>

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Genetic associations between post-traumatic stress disorder and REM-sleep behavior disorder

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月21日

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  • Morvarid Ghamgosar Shahkhali,
  • Lang Liu,
  • Mohammad H. Ghamgosar Shahkhali,
  • Eric Yu,
  • Farnaz Asayesh,
  • Jamil Ahmad,
  • Meron Teferra,
  • Isabelle Arnulf,
  • Pauline Dodet,
  • Yo-El Ju,
  • Michele T. M. Hu,
  • Jacques Y. Montplaisir,
  • Jean-François Gagnon,
  • Alex Desautels,
  • Abubaker Ibrahim,
  • Ambra Stefani,
  • Birgit Högl,
  • Merve Aktan-Süzgün,
  • Alex Iranzo,
  • Mónica Serradell,
  • Angelica Montini,
  • Gerard Maya,
  • Carles Gaig,
  • Gian Luigi Gigli,
  • Mariarosaria Valente,
  • Francesco Janes,
  • Andrea Bernardini,
  • Yves Dauvilliers,
  • Karel Sonka,
  • David Kemlink,
  • Petr Dusek,
  • Michael Sommerauer,
  • Gültekin Tamgüney,
  • Michela Figorilli,
  • Monica Puligheddu,
  • Valerie Cochen De Cock,
  • Wolfgang Oertel,
  • Annette Janzen,
  • Elena Antelmi,
  • Brit Mollenhauer,
  • Friederike Sixel-Doring,
  • Michele Terzaghi,
  • Giuseppe Fiamingo,
  • Matej Skorvanek,
  • Kristina Kulcsarova,
  • Beatriz Abril,
  • Luigi Ferini-Strambi,
  • Jitka Bušková,
  • Beatrice Orso,
  • Pietro Mattioli,
  • Dario Arnaldi,
  • Femke Dijkstra,
  • Mineke Viaene,
  • Bradley F. Boeve,
  • Owen A. Ross,
  • Guy A. Rouleau,
  • Lee E. Neilson,
  • Jonathan E. Elliott,
  • Miranda M. Lim,
  • Ronald B. Postuma,
  • Ziv Gan-Or

摘要

Isolated/idiopathic rapid-eye movement (REM) sleep behavior disorder (iRBD) is, in most cases, an early form of α -synuclein-related neurodegenerative diseases, including Parkinson’s disease and dementia with Lewy bodies. Clinical reports suggest that iRBD is more common in individuals with Post-Traumatic Stress Disorder (PTSD) compared to those without PTSD. We conducted polygenic risk score (PRS), genetic correlation, and Mendelian randomization analyses to explore potential genetic and/or causal associations between PTSD and iRBD. Dopamine transporter imaging binding status was also examined in iRBD patients with (N = 6) and without PTSD (N = 32). While not supporting a causal relationship, genetic analyses revealed a significant association between PTSD and iRBD, consistent with the exploratory imaging substudy. These findings suggest that individuals genetically at risk for PTSD may also be at higher risk for iRBD. Further investigation of iRBD in individuals with PTSD may help inform potential neurodegenerative risk.