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<p>Non-motor symptoms (NMS) in Parkinson’s Disease (PD) encompass a variety of symptoms which may differ in terms of presentation and severity according to gender. However, literature evidences are often conflicting due to the use of different instruments. The Non-Motor Symptoms Scale (NMSS) is a validated tool widely used to holistically assess NMSs in PD. We aimed to summarize available data on gender differences in NMS severity in PD using the NMSS. A literature review has been performed in the PubMed and Scopus databases up to 1<sup>st</sup> February 2025. A random effect model was used to report pooled effects. Nine full text articles have been included in the analysis, pooling the data of 4352 PD patients [N = 2453 (58%) men]. Women showed higher symptoms severity in mood/cognition whereas higher severity in the sexual domain was found in men. These findings highlight the need for a specific gender-related approach in PD.</p>

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Sex differences in the severity of non-motor symptoms in Parkinson’s disease: a systematic review and meta-analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月18日

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  • Calogero Edoardo Cicero,
  • Claudio Terravecchia,
  • Lavinia Lucia Pettinato,
  • Silvia Tabbì,
  • Giulia Donzuso,
  • Donatella Contrafatto,
  • Giovanni Mostile,
  • Mario Zappia,
  • Alessandra Nicoletti

摘要

Non-motor symptoms (NMS) in Parkinson’s Disease (PD) encompass a variety of symptoms which may differ in terms of presentation and severity according to gender. However, literature evidences are often conflicting due to the use of different instruments. The Non-Motor Symptoms Scale (NMSS) is a validated tool widely used to holistically assess NMSs in PD. We aimed to summarize available data on gender differences in NMS severity in PD using the NMSS. A literature review has been performed in the PubMed and Scopus databases up to 1st February 2025. A random effect model was used to report pooled effects. Nine full text articles have been included in the analysis, pooling the data of 4352 PD patients [N = 2453 (58%) men]. Women showed higher symptoms severity in mood/cognition whereas higher severity in the sexual domain was found in men. These findings highlight the need for a specific gender-related approach in PD.