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<p>Detection of alpha-synuclein (α-Syn) seeding activity in tear fluid (TF) offers a promising non-invasive biomarker for Parkinson’s disease (PD). α-Syn seeding amplification assay (αSynSAA) detected seeding activity in 67% of PD-TF, while non-synucleinopathy samples remained negative. Electron microscopy of seeding-positive end products revealed fibrillar structures morphologically consistent with results of αSynSAA. αSynSAA effectively distinguished PD from controls and prion diseases based on seeding activity in TF.</p>

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Detection of alpha-synuclein seeding activity in tear fluid in patients with Parkinson’s disease

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月18日

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  • Sezgi Canaslan,
  • Matthias Schmitz,
  • Fabian Maass,
  • Peter Hermann,
  • Susana Da Silva Correia,
  • Shuyu Zhang,
  • Bastian Popper,
  • Wiebke Möbius,
  • Christoph van Riesen,
  • Piero Parchi,
  • Paul Lingor,
  • Inga Zerr

摘要

Detection of alpha-synuclein (α-Syn) seeding activity in tear fluid (TF) offers a promising non-invasive biomarker for Parkinson’s disease (PD). α-Syn seeding amplification assay (αSynSAA) detected seeding activity in 67% of PD-TF, while non-synucleinopathy samples remained negative. Electron microscopy of seeding-positive end products revealed fibrillar structures morphologically consistent with results of αSynSAA. αSynSAA effectively distinguished PD from controls and prion diseases based on seeding activity in TF.