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<p>Previous studies suggest there are distinct gut microbial and functional variations in patients with Parkinson’s disease (PwPD) that may reveal potential microbiome signatures or biomarkers to aid in early detection of the disease. In this case-control study, we used whole genome sequencing to compare the stool samples of 55 PwPD to 42 healthy controls (HC) from a public database (BioProject Accession PRJEB39223). For bacterial phyla, we observed a greater relative abundance in <i>Firmicutes</i> and <i>Actinobacteria</i> among PwPD, while that of <i>Bacteroidetes</i> was lower. For phages, PwPD had a greater relative abundance of <i>Siphoviridae, Tectiviridae, and Podoviridae</i>, while <i>Microviridae</i> was lower. Moreover, we described 10 functional pathways that most significantly differed between PwPD and HC (all <i>P</i> &lt; 0.0001). In conclusion, significant differences were observed in gut bacteria, phages, and functional pathways between PwPD and HC that both support and conflict with previous case-control studies and warrant further validation.</p>

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Metagenomics indicates an interplay of the microbiome and functional pathways in Parkinson’s disease

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月30日

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  • Sarah Jaehwa Park,
  • Barış Erhan Özdinç,
  • Kathryn Grace Coker,
  • Dana M. Walsh,
  • Devon J. Fox,
  • Samantha Evans,
  • Joshua Farahnik,
  • Kelly Moffat,
  • Margaret Boomgaarden,
  • Laurie K. Mischley

摘要

Previous studies suggest there are distinct gut microbial and functional variations in patients with Parkinson’s disease (PwPD) that may reveal potential microbiome signatures or biomarkers to aid in early detection of the disease. In this case-control study, we used whole genome sequencing to compare the stool samples of 55 PwPD to 42 healthy controls (HC) from a public database (BioProject Accession PRJEB39223). For bacterial phyla, we observed a greater relative abundance in Firmicutes and Actinobacteria among PwPD, while that of Bacteroidetes was lower. For phages, PwPD had a greater relative abundance of Siphoviridae, Tectiviridae, and Podoviridae, while Microviridae was lower. Moreover, we described 10 functional pathways that most significantly differed between PwPD and HC (all P < 0.0001). In conclusion, significant differences were observed in gut bacteria, phages, and functional pathways between PwPD and HC that both support and conflict with previous case-control studies and warrant further validation.