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<p>Reduction in neuronal firing from wake to sleep, i.e., sleep <i>firing rate homeostasis (sFRH</i>), is essential for restorative sleep. Sleep dysfunction is common in Parkinson’s disease (PD), but sFRH has not been investigated. Here, using a within-subject design in the nonhuman primate model of PD, we report that thalamocortical sFRH is disrupted in parkinsonism. These findings can inform therapeutic approaches tailored to normalize sFRH and reestablish restorative sleep in PD.</p>

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Sleep firing rate homeostasis is disrupted in mild parkinsonism

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月21日

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  • Bharadwaj Nandakumar,
  • Ajay K. Verma,
  • Ying Yu,
  • Ethan Marshall,
  • Adele L. DeNicola,
  • Jing Wang,
  • Colum D. MacKinnon,
  • Michael J. Howell,
  • Jerrold L. Vitek,
  • Luke A. Johnson

摘要

Reduction in neuronal firing from wake to sleep, i.e., sleep firing rate homeostasis (sFRH), is essential for restorative sleep. Sleep dysfunction is common in Parkinson’s disease (PD), but sFRH has not been investigated. Here, using a within-subject design in the nonhuman primate model of PD, we report that thalamocortical sFRH is disrupted in parkinsonism. These findings can inform therapeutic approaches tailored to normalize sFRH and reestablish restorative sleep in PD.