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<p>Aging is the most significant risk factor for Parkinson’s disease (PD), yet its role remains underexplored. The International Network for Parkinson’s Disease Modelling and Aging (PD-AGE), funded by the Michael J. Fox Foundation, was established to address these challenges. Through collaborative efforts, the PD-AGE mouse-model working group developed a roadmap to prioritize mouse models, reach consensus on experimental approaches, and standardize protocols to investigate the intersection of aging and PD.</p>

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Unraveling the intersection of aging and Parkinson’s disease: a collaborative roadmap for advancing research models

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月16日

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  • M. Y. Schmidt,
  • A. M. Cuervo,
  • K. L. Double,
  • D. Ehninger,
  • M. S. Goldberg,
  • K. Harvey,
  • J. H. J. Hoeijmakers,
  • K. C. Luk,
  • P. G. Mastroberardino,
  • D. J. Moore,
  • L. J. Niedernhofer,
  • L. É. Trudeau,
  • D. Jurk,
  • J. K. Andersen,
  • I. Bellantuono

摘要

Aging is the most significant risk factor for Parkinson’s disease (PD), yet its role remains underexplored. The International Network for Parkinson’s Disease Modelling and Aging (PD-AGE), funded by the Michael J. Fox Foundation, was established to address these challenges. Through collaborative efforts, the PD-AGE mouse-model working group developed a roadmap to prioritize mouse models, reach consensus on experimental approaches, and standardize protocols to investigate the intersection of aging and PD.