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<p>Parkinson’s Disease (PD) is a progressive neurodegenerative disorder. Depression, a prevalent comorbidity across all stages, exacerbates PD severity. α-synuclein aggregation, the hallmark of PD, drives pathways overlapping with depression. This review places α-synuclein at the nexus of mechanistic synergy between PD and depression, and incorporates secondary analyses of genomic and transcriptomic datasets to identify convergent genes and pathways, underscoring depression’s potential as a biomarker for diagnosis and progression of PD.</p>

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α-synuclein in Parkinson’s disease: a central point of convergence with depression

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月20日

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  • Ayesha M. Yusuf,
  • Burcu Yener Ilce,
  • Hamid A. Alhaj,
  • Rifat Hamoudi

摘要

Parkinson’s Disease (PD) is a progressive neurodegenerative disorder. Depression, a prevalent comorbidity across all stages, exacerbates PD severity. α-synuclein aggregation, the hallmark of PD, drives pathways overlapping with depression. This review places α-synuclein at the nexus of mechanistic synergy between PD and depression, and incorporates secondary analyses of genomic and transcriptomic datasets to identify convergent genes and pathways, underscoring depression’s potential as a biomarker for diagnosis and progression of PD.