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<p>Alpha-synuclein (AS) accumulation is more frequently detected in the stomach than in the colon of patients with Parkinson’s disease (PD), suggesting its potential as a pathologic biomarker. This study is to evaluate the diagnostic performance of real-time quaking-induced conversion assay on stomach biopsies for early PD and its association with clinical characteristics. Stomach biopsy tissues were prospectively collected from 22 patients with early-stage PD and 17 controls. Pathological AS-seeding activity was assessed, and correlations between kinematic parameters and clinical features were analyzed with age adjustment. Pathological AS-seeding activity was detected in 45.5% of patients with PD and in none of the controls. The Montreal Cognitive Assessment score was correlated with the lag time of positive replicates (Spearman’s <i>ρ</i> = 0.742; <i>p</i> = 0.022), after age adjustment. The AS seed amplification assay using the stomach tissue may serve as a biomarker reflecting disease pathophysiology of the gut–brain axis in PD.</p>

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Cognitive function correlates with gastric alpha-synuclein seeding activity in early Parkinson’s disease

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月4日

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  • Chaewon Shin,
  • Jong Pil Im,
  • Jung-Youn Han,
  • Bora Jin,
  • Kyung Ah Woo,
  • Seungmin Lee,
  • HoYoung Jeon,
  • Jae Young Joo,
  • Hee Jin Chang,
  • Jung Hwan Shin,
  • Han-Joon Kim,
  • Jong-Min Kim,
  • Young Pyo Choi,
  • Beomseok Jeon

摘要

Alpha-synuclein (AS) accumulation is more frequently detected in the stomach than in the colon of patients with Parkinson’s disease (PD), suggesting its potential as a pathologic biomarker. This study is to evaluate the diagnostic performance of real-time quaking-induced conversion assay on stomach biopsies for early PD and its association with clinical characteristics. Stomach biopsy tissues were prospectively collected from 22 patients with early-stage PD and 17 controls. Pathological AS-seeding activity was assessed, and correlations between kinematic parameters and clinical features were analyzed with age adjustment. Pathological AS-seeding activity was detected in 45.5% of patients with PD and in none of the controls. The Montreal Cognitive Assessment score was correlated with the lag time of positive replicates (Spearman’s ρ = 0.742; p = 0.022), after age adjustment. The AS seed amplification assay using the stomach tissue may serve as a biomarker reflecting disease pathophysiology of the gut–brain axis in PD.