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<p>Exercise offers neuroprotective benefits in Parkinson’s disease (PD) by enhancing neurotrophic factors (e.g., BDNF, GDNF), improving mitochondrial function, reducing inflammation, and promoting autophagy. Irisin, a muscle-derived cytokine, links exercise to neuronal health by regulating mitochondria and mitigating oxidative stress. Notably, irisin may serve as a therapeutic target for patients unable to exercise. Thus, exercise is a promising non-pharmacological intervention warranting further research for novel PD therapies.</p>

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New perspectives on molecular mechanisms underlying exercise-induced benefits in Parkinson’s disease

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年8月23日

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  • Xingyue Chen,
  • Guoxin Zhang,
  • Miao Liu,
  • Juanfeng He,
  • Zhentao Zhang

摘要

Exercise offers neuroprotective benefits in Parkinson’s disease (PD) by enhancing neurotrophic factors (e.g., BDNF, GDNF), improving mitochondrial function, reducing inflammation, and promoting autophagy. Irisin, a muscle-derived cytokine, links exercise to neuronal health by regulating mitochondria and mitigating oxidative stress. Notably, irisin may serve as a therapeutic target for patients unable to exercise. Thus, exercise is a promising non-pharmacological intervention warranting further research for novel PD therapies.