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<p>The secretion of α-synuclein from presynaptic terminals is controlled by neuronal activity through a calcium-dependent mechanism. To address the role of voltage gated calcium channels in this process, we used reverse brain microdialysis to monitor α-synuclein release in vivo in the presence of selective channel inhibitors. Our results revealed that the ω-conotoxin GVIA-sensitive N-type calcium channels are the major mediators of stimulated α-synuclein secretion in mouse striatum.</p>

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N-type Ca2+ channels mediate the stimuli-dependent α-synuclein secretion in mouse striatum

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月26日

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  • Emmanouela Leandrou,
  • Ioanna Chalatsa,
  • Kostas Vekrellis,
  • Evangelia Emmanouilidou

摘要

The secretion of α-synuclein from presynaptic terminals is controlled by neuronal activity through a calcium-dependent mechanism. To address the role of voltage gated calcium channels in this process, we used reverse brain microdialysis to monitor α-synuclein release in vivo in the presence of selective channel inhibitors. Our results revealed that the ω-conotoxin GVIA-sensitive N-type calcium channels are the major mediators of stimulated α-synuclein secretion in mouse striatum.