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<p>This study assessed the prognostic value of probabilistic sleep staging in early PD by quantifying sleep stage uncertainty and mixing. Data from two longitudinal cohorts (DeNoPa and ICEBERG) included 280 patients with early PD (mean duration 21.1 months) and 158 matched controls. Sleep stages were scored automatically using U-Sleep, which provides for each 30-s epoch a probabilistic distribution of wakefulness (W), NREM stage N1, N2, N3, and REM sleep. Uncertainty (percentage of sleep stages with less than 80% certainty) and mixed stages were quantified. PD patients showed higher sleep stage uncertainty and wake–N3 mixing, especially those with REM sleep behavior disorder. Greater W–N3 mixing was associated with worse motor and cognitive scores at baseline and with faster motor decline over time. EEG features of this mixing suggested unstable deep sleep. These findings support the value of automated sleep analysis to detect microstructural sleep disruptions linked to PD progression.</p>

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Sleep stage mixing is associated with poor prognosis in early Parkinson’s disease

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月26日

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  • Pauline Dodet,
  • Emmanuel During,
  • Isabelle Arnulf,
  • Claudia Trenkwalder,
  • Brit Mollenhauer,
  • Friederike Sixel-Döring,
  • Emmanuel Roze,
  • Marie Vidailhet,
  • Thomas Andrillon,
  • Stéphane Lehericy,
  • Jean-Christophe Corvol,
  • Graziella Mangone,
  • Smaranda Leu-Semenescu,
  • Emmanuel Mignot,
  • Poul Jennum,
  • Andreas Brink-Kjaer

摘要

This study assessed the prognostic value of probabilistic sleep staging in early PD by quantifying sleep stage uncertainty and mixing. Data from two longitudinal cohorts (DeNoPa and ICEBERG) included 280 patients with early PD (mean duration 21.1 months) and 158 matched controls. Sleep stages were scored automatically using U-Sleep, which provides for each 30-s epoch a probabilistic distribution of wakefulness (W), NREM stage N1, N2, N3, and REM sleep. Uncertainty (percentage of sleep stages with less than 80% certainty) and mixed stages were quantified. PD patients showed higher sleep stage uncertainty and wake–N3 mixing, especially those with REM sleep behavior disorder. Greater W–N3 mixing was associated with worse motor and cognitive scores at baseline and with faster motor decline over time. EEG features of this mixing suggested unstable deep sleep. These findings support the value of automated sleep analysis to detect microstructural sleep disruptions linked to PD progression.