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<p>There is a relative dearth of research on patients with Parkinson’s disease (PD) from under-represented ethnic groups in the United Kingdom. The East London Parkinson Disease project seeks to understand the clinical manifestations and determinants of PD in a diverse population. Data on clinical features were collected, between 2019 and 2024. We assessed 218 patients with PD and 90 controls. Among them, 50% of patients and 64% controls identified as South Asian or Black. South Asian and Black patients had significantly worse motor scores compared to White patients (mean [SD], 42.2 [18.8], and 47.0 [16.6] vs 35.2 [16.4], <i>p</i> &lt; 0.001 and <i>p</i> &lt; 0.001). Cognitive impairment was more prevalent in South Asian (73%) and Black patients (75%) than in White patients (45%, <i>p</i> = 0.002). Our results suggest that patients with PD from South Asian and Black ethnic groups may have more severe motor and certain non-motor features, including cognitive impairment, compared to White patients.</p>

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The East London Parkinson’s disease project – a case-control study of Parkinson’s Disease in a diverse population

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月17日

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  • Alexandra Zirra,
  • Kamalesh C. Dey,
  • Ellen Camboe,
  • Sheena Waters,
  • Tahrina Haque,
  • Brook Huxford,
  • Harneek Chohan,
  • Natalie Donkor,
  • Joshua Kahan,
  • Aaron Ben-Joseph,
  • David A. Gallagher,
  • Caroline Budu,
  • Thomas Boyle,
  • Cristina Simonet,
  • Andrew J. Lees,
  • Charles R. Marshall,
  • Alastair J. Noyce

摘要

There is a relative dearth of research on patients with Parkinson’s disease (PD) from under-represented ethnic groups in the United Kingdom. The East London Parkinson Disease project seeks to understand the clinical manifestations and determinants of PD in a diverse population. Data on clinical features were collected, between 2019 and 2024. We assessed 218 patients with PD and 90 controls. Among them, 50% of patients and 64% controls identified as South Asian or Black. South Asian and Black patients had significantly worse motor scores compared to White patients (mean [SD], 42.2 [18.8], and 47.0 [16.6] vs 35.2 [16.4], p < 0.001 and p < 0.001). Cognitive impairment was more prevalent in South Asian (73%) and Black patients (75%) than in White patients (45%, p = 0.002). Our results suggest that patients with PD from South Asian and Black ethnic groups may have more severe motor and certain non-motor features, including cognitive impairment, compared to White patients.