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<p>The proposed Neuronal α-Synuclein Disease Integrated Staging System (NSD-ISS) was recently applied to early Parkinson’s disease (PD) cohorts. We applied this research framework to the BioFIND study cohort, which includes more moderately advanced PD participants with clinically established PD. Disease durations within each ISS stage were highly variable. Cognitive and non-motor anchors had little weight in determining staging. The analysis highlights strengths and limitations of NSD-ISS to guide further refinement of an integrated staging system.</p>

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New diagnostic and staging framework applied to established PD in the BioFIND cohort

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月4日

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  • Marco J. Russo,
  • Un Jung Kang,
  • Roy N. Alcalay,
  • Amy Amara,
  • Vanessa Arnedo,
  • Samuel Frank,
  • Mark Frasier,
  • Jennifer G. Goldman,
  • Katrina Gwinn,
  • Claire Henchcliffe,
  • Penelope Hogarth,
  • Anna Naito,
  • Alyssa N. Reimer,
  • Marie-Helene Saint-Hilaire,
  • Christine Swanson-Fischer,
  • Margaret Sutherland,
  • Paul Tuite,
  • Tao Xie

摘要

The proposed Neuronal α-Synuclein Disease Integrated Staging System (NSD-ISS) was recently applied to early Parkinson’s disease (PD) cohorts. We applied this research framework to the BioFIND study cohort, which includes more moderately advanced PD participants with clinically established PD. Disease durations within each ISS stage were highly variable. Cognitive and non-motor anchors had little weight in determining staging. The analysis highlights strengths and limitations of NSD-ISS to guide further refinement of an integrated staging system.