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<p>The influence of Lewy body (LB) and tau co-pathologies is increasingly acknowledged as putatively affecting neurodegeneration and clinical phenotypes. Here, we injected rhesus macaques with LB fractions or/and tau seeds derived from patients brains into distinct brain areas connected to the mesencephalon. Compared to control macaques, we observed increased mesencephalic staining of pathological α-synuclein and tau, as well as nigrostriatal dopaminergic neuronal loss, with a cumulative effect of co-pathology.</p>

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Additive effect of distant Lewy bodies and tau seeds injections on nigral degeneration in macaques

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月13日

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  • Morgane Darricau,
  • Valentine Kulifaj,
  • Marie-Laure Arotcarena,
  • Qin Li,
  • Taxiarchis Katsinelos,
  • William A. McEwan,
  • Maria Xilouri,
  • Benjamin Dehay,
  • Erwan Bezard,
  • Vincent Planche

摘要

The influence of Lewy body (LB) and tau co-pathologies is increasingly acknowledged as putatively affecting neurodegeneration and clinical phenotypes. Here, we injected rhesus macaques with LB fractions or/and tau seeds derived from patients brains into distinct brain areas connected to the mesencephalon. Compared to control macaques, we observed increased mesencephalic staining of pathological α-synuclein and tau, as well as nigrostriatal dopaminergic neuronal loss, with a cumulative effect of co-pathology.