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<p>A comprehensive, patient-centered conceptual model of early Parkinson’s is lacking and is greatly needed. A systematic review and meta-synthesis of qualitative and quantitative research was conducted by a multi-stakeholder taskforce using JBI Mixed Methods Review criteria and GRADE-CERQual standards for assessment of evidence. Over 340 symptoms and impacts were identified across ten symptom domains (Movement, Cognitive, Psychiatric, Sleep, Sensory, Speech, Digestive, Urinary, Sexual, Autonomic) and two impact domains (Physical and Psychosocial functioning). A wide range of motor and non-motor symptoms were present in early disease, with strongest support for tremor, dexterity, gait, stiffness, slow movements, cognitive, mood, and sleep alterations, urinary dysfunction, constipation, pain, and fatigue. These affected mobility, self-concept, coping, effort of living, interactions and important activities, with evidence of many understudied concepts. This model offers the most comprehensive catalogue of symptoms and impacts in Parkinson’s to date and will support clinical practice and endpoint selection for therapeutic trials.</p>

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Systematic review and consensus conceptual model of meaningful symptoms and functional impacts in early Parkinson’s Disease

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月3日

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  • Jennifer R. Mammen,
  • Jamie L. Adams,
  • Rikki Mangrum,
  • Yuge Xiao,
  • William Barbosa,
  • Mirinda Tyo,
  • Christopher Redmond,
  • Cheryl Carter,
  • Kelly Cifelli,
  • Robert Cifelli,
  • Hope Maruzo,
  • Jim Meeker,
  • Gerry Shultz,
  • Colbren Thomas,
  • Claire Bale,
  • Evan Davies,
  • Catherine M. Kopil,
  • Connie Marras,
  • Tiago Mestre,
  • Thomas Morel,
  • Tanya Simuni,
  • Glenn T. Stebbins,
  • Daniel Weintraub,
  • Diane Stephenson

摘要

A comprehensive, patient-centered conceptual model of early Parkinson’s is lacking and is greatly needed. A systematic review and meta-synthesis of qualitative and quantitative research was conducted by a multi-stakeholder taskforce using JBI Mixed Methods Review criteria and GRADE-CERQual standards for assessment of evidence. Over 340 symptoms and impacts were identified across ten symptom domains (Movement, Cognitive, Psychiatric, Sleep, Sensory, Speech, Digestive, Urinary, Sexual, Autonomic) and two impact domains (Physical and Psychosocial functioning). A wide range of motor and non-motor symptoms were present in early disease, with strongest support for tremor, dexterity, gait, stiffness, slow movements, cognitive, mood, and sleep alterations, urinary dysfunction, constipation, pain, and fatigue. These affected mobility, self-concept, coping, effort of living, interactions and important activities, with evidence of many understudied concepts. This model offers the most comprehensive catalogue of symptoms and impacts in Parkinson’s to date and will support clinical practice and endpoint selection for therapeutic trials.