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<p>Evidence regarding brain structural atrophy associated with Freezing of Gait (FOG) in Parkinson’s disease (PD) is inconsistent. We analyzed cortical thickness and subcortical nuclei volumes using FreeSurfer in two large PD cohorts. In cohort 1 (<i>N</i> = 316), multivariate analyses identified reduced pallidum and ventral diencephalon (VDC) volumes as significantly associated with FOG presence. Validation in the Parkinson’s Progression Markers Initiative (PPMI) cohort (cohort 2, <i>N</i> = 94) demonstrated that decreased VDC volume at four-year follow-up independently predicted higher FOG risk, improving the predictive model’s accuracy when combined with PIGD score, CSF Aβ42, and caudate DAT uptake (AUC 0.760; Δ<i>χ</i><sup>2</sup> = 5.449, <i>P</i> = 0.020; <i>Z</i> = 2.211, <i>P</i> = 0.027). VDC volume is also correlated with FOG severity. These findings suggest that VDC atrophy may underlie FOG mechanisms and serve as a biomarker for its progression in PD patients.</p>

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Atrophy of ventral diencephalon is associated with freezing of gait in Parkinson’s disease: analysis of two cohorts

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月6日

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  • Xuemei Wang,
  • Huimin Chen,
  • Xinxin Ma,
  • Huijing Liu,
  • Dongdong Wu,
  • Wei Du,
  • Jing He,
  • Shuhua Li,
  • Haibo Chen,
  • Tao Wu,
  • Tao Feng,
  • Wen Su

摘要

Evidence regarding brain structural atrophy associated with Freezing of Gait (FOG) in Parkinson’s disease (PD) is inconsistent. We analyzed cortical thickness and subcortical nuclei volumes using FreeSurfer in two large PD cohorts. In cohort 1 (N = 316), multivariate analyses identified reduced pallidum and ventral diencephalon (VDC) volumes as significantly associated with FOG presence. Validation in the Parkinson’s Progression Markers Initiative (PPMI) cohort (cohort 2, N = 94) demonstrated that decreased VDC volume at four-year follow-up independently predicted higher FOG risk, improving the predictive model’s accuracy when combined with PIGD score, CSF Aβ42, and caudate DAT uptake (AUC 0.760; Δχ2 = 5.449, P = 0.020; Z = 2.211, P = 0.027). VDC volume is also correlated with FOG severity. These findings suggest that VDC atrophy may underlie FOG mechanisms and serve as a biomarker for its progression in PD patients.