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<p>Recent advances in optical technologies have opened new possibilities for electrophysiological interfacing, offering alternatives to traditional electrically-based methods. Here, we present a flexible optical-electrode ‘optrode’ that employs a passive transduction mechanism to convert biopotentials into quantifiable optical signals. Our design integrates liquid crystals into a multilayered polymeric structure that enables light transmission and reflection while carrying the signal to a photodetection system with a relative responsivity of 13 ± 1%/V and an operating bandwidth of 2.2 ± 0.1 kHz for electrophysiology applications (<i>N</i> = 25 total measurements). Additionally, we demonstrated its cytocompatibility and effectiveness in detecting electrograms from cardiac tissues. This approach addresses major limitations of biomedical optoelectronics, providing label-free and conductive lead-free signal detection while maintaining a soft, tissue-like interface and demonstrating strong potential for integration into advanced electrophysiological platforms.</p>

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Flexible polymer-based liquid crystal sensor for label-free electro-optical recording of electrophysiological activity

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月30日

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  • Reem. M. Almasri,
  • Yingge Chen,
  • François Ladouceur,
  • Ulises A. Aregueta Robles,
  • Zihan Feng,
  • Laura A. Poole-Warren,
  • Nigel H. Lovell,
  • Amr Al Abed

摘要

Recent advances in optical technologies have opened new possibilities for electrophysiological interfacing, offering alternatives to traditional electrically-based methods. Here, we present a flexible optical-electrode ‘optrode’ that employs a passive transduction mechanism to convert biopotentials into quantifiable optical signals. Our design integrates liquid crystals into a multilayered polymeric structure that enables light transmission and reflection while carrying the signal to a photodetection system with a relative responsivity of 13 ± 1%/V and an operating bandwidth of 2.2 ± 0.1 kHz for electrophysiology applications (N = 25 total measurements). Additionally, we demonstrated its cytocompatibility and effectiveness in detecting electrograms from cardiac tissues. This approach addresses major limitations of biomedical optoelectronics, providing label-free and conductive lead-free signal detection while maintaining a soft, tissue-like interface and demonstrating strong potential for integration into advanced electrophysiological platforms.