Scholarlink

<p>Antibiotic administration is the mainstay for treating bacterial infections, but multidrug-resistant (MDR) bacteria jeopardize its effectiveness. Antimicrobial photodynamic therapy (aPDT) offers a promising strategy with less risk of inducing resistance, yet the lack of a suitable wearable light source limits its widespread adoption. Here, we design flexible quantum dot light-emitting diodes (F-QLEDs) for effective aPDT treatment of MDR bacteria. By simultaneous optical, thermal, and reliability management, we achieved F-QLEDs with emission spectrum matching the photosensitizer absorption, physiologically safe surface temperature (&lt;41 °C), enhanced operating lifetime (7.5X), and ambient shelf life &gt; 1 month. Subsequently, aPDT testing demonstrated a ~ 9-log reduction of <i>Staphylococcus aureus</i> and ~2-3 log reduction of <i>Pseudomonas aeruginosa</i> compared to controls. Additionally, testing with different photosensitizers confirmed F-QLED versatility for targeted aPDT. These results showcase the potent antimicrobial efficacy of F-QLEDs and their potential as wearable optical platforms for point-of-care treatment of MDR infections and broader photomedical applications.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Advancing flexible quantum dot light-emitting diode technology for antimicrobial photodynamic therapy

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月6日

查看全文
  • Manuel A. Triana,
  • Yanfang Feng,
  • Shruti Jayaprakash Saiji,
  • Yiteng Tang,
  • Raymond J. Lanzafame,
  • Natalie Kay Eidenschink,
  • Shakir Khan,
  • Yajie Dong,
  • Tayyaba Hasan

摘要

Antibiotic administration is the mainstay for treating bacterial infections, but multidrug-resistant (MDR) bacteria jeopardize its effectiveness. Antimicrobial photodynamic therapy (aPDT) offers a promising strategy with less risk of inducing resistance, yet the lack of a suitable wearable light source limits its widespread adoption. Here, we design flexible quantum dot light-emitting diodes (F-QLEDs) for effective aPDT treatment of MDR bacteria. By simultaneous optical, thermal, and reliability management, we achieved F-QLEDs with emission spectrum matching the photosensitizer absorption, physiologically safe surface temperature (<41 °C), enhanced operating lifetime (7.5X), and ambient shelf life > 1 month. Subsequently, aPDT testing demonstrated a ~ 9-log reduction of Staphylococcus aureus and ~2-3 log reduction of Pseudomonas aeruginosa compared to controls. Additionally, testing with different photosensitizers confirmed F-QLED versatility for targeted aPDT. These results showcase the potent antimicrobial efficacy of F-QLEDs and their potential as wearable optical platforms for point-of-care treatment of MDR infections and broader photomedical applications.