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<p>Transparent electro-optical neural interfacing technologies offer simultaneous high-spatial-resolution microscopic imaging, and high-temporal-resolution electrical recording and stimulation. However, fabricating transparent, flexible, and mechanically robust neural electrodes with high electrochemical performance remains challenging. In this study, we fabricated transparent (72.7% at 570 nm), mechanically robust (0.05% resistance change after 50k bending cycles) ultrathin Au microelectrodes for micro-electrocorticography (µECoG) using a hexadentate metal-polymer ligand bonding with an EDTA/PSS seed layer. These transparent µECoG arrays, fabricated with biocompatible gold, exhibit excellent electrochemical properties (0.73 Ω·cm<sup>2</sup>) for neural recording and stimulation with long-term stability. We recorded brain surface waves in vivo, maintaining a low baseline noise and a high signal-to-noise ratio during acute and two-week recordings. In addition, we successfully performed optogenetic modulation without light-induced artifacts at 7.32 mW/mm<sup>2</sup> laser power density. This approach shows great potential for scalable, implantable neural electrodes and wearable optoelectronic devices in digital healthcare systems.</p>

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Hexagonal metal complex based mechanically robust transparent ultrathin gold µECoG for electro-optical neural interfaces

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月11日

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  • Duhee Kim,
  • Murali Bissannagari,
  • Boil Kim,
  • Nari Hong,
  • Jaeu Park,
  • Hyeongtae Lim,
  • Junhee Lee,
  • Jungha Lee,
  • Yoon Kyoung Kim,
  • Youngjae Cho,
  • Kwang Lee,
  • Junghyup Lee,
  • Jong-Hyeok Yoon,
  • Jae Eun Jang,
  • David Tsai,
  • Sanghoon Lee,
  • Hyuk-Jun Kwon,
  • Han Kyoung Choe,
  • Hongki Kang

摘要

Transparent electro-optical neural interfacing technologies offer simultaneous high-spatial-resolution microscopic imaging, and high-temporal-resolution electrical recording and stimulation. However, fabricating transparent, flexible, and mechanically robust neural electrodes with high electrochemical performance remains challenging. In this study, we fabricated transparent (72.7% at 570 nm), mechanically robust (0.05% resistance change after 50k bending cycles) ultrathin Au microelectrodes for micro-electrocorticography (µECoG) using a hexadentate metal-polymer ligand bonding with an EDTA/PSS seed layer. These transparent µECoG arrays, fabricated with biocompatible gold, exhibit excellent electrochemical properties (0.73 Ω·cm2) for neural recording and stimulation with long-term stability. We recorded brain surface waves in vivo, maintaining a low baseline noise and a high signal-to-noise ratio during acute and two-week recordings. In addition, we successfully performed optogenetic modulation without light-induced artifacts at 7.32 mW/mm2 laser power density. This approach shows great potential for scalable, implantable neural electrodes and wearable optoelectronic devices in digital healthcare systems.