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<p>Spaceflight acutely but transiently elevates intraocular pressure (IOP), often attributed to cephalad fluid shift and choroidal expansion. We propose that anterior segment mechanics, including lens–iris diaphragm position and conventional outflow loading, may contribute to early IOP changes. Comparing phakic and pseudophakic eyes, paired with anterior segment OCT and complementary imaging aboard the International Space Station, could define mechanisms and inform astronaut screening and ocular risk mitigation.</p>

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Anterior segment biomechanics and intraocular pressure in microgravity: implications for future spaceflight studies

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月30日

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  • Alex Weaver,
  • Joshua Ong,
  • Baltaj S. Sandhur,
  • Ritu Sampige,
  • Alexander Black,
  • Andrew G. Lee,
  • John Berdahl,
  • C. Robert Gibson,
  • Thomas H. Mader

摘要

Spaceflight acutely but transiently elevates intraocular pressure (IOP), often attributed to cephalad fluid shift and choroidal expansion. We propose that anterior segment mechanics, including lens–iris diaphragm position and conventional outflow loading, may contribute to early IOP changes. Comparing phakic and pseudophakic eyes, paired with anterior segment OCT and complementary imaging aboard the International Space Station, could define mechanisms and inform astronaut screening and ocular risk mitigation.