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<p>Microgravity strongly affects human physiology during spaceflight. Biological sex has not yet been sufficiently considered as a variable for spaceflight deconditioning. The VivalDI studies investigated physiological systems affected by 5-days dry immersion (DI) in females and males, with a focus on immune changes in this report. In both sexes proportions of peripheral granulocytes and NK cells were elevated during DI and T-cell numbers were reduced. Leukocyte activation and cytokine levels were moderately affected. Females showed a higher Torque-Teno-virus shedding at the end of DI. Noradrenaline concentrations increased during the study with sex-specific patterns. Hemodynamics suggest that immunological changes were caused by DI-induced fluid shifts. Moreover, male study participants’ patterns were compared to a historical data set from a 5-days head-down-tilt bed rest (HDT-BR) study. Changes in leukocyte proportions and body fluid indicators were stronger in DI versus HDT-BR. These analyses indicate that fluid shifts primarily drive intervention-related immune-physiological differences, independent of biological sex. ClinicalTrials.gov, TRN: NCT05043974 and NCT05493176.</p>

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Fluid shifts are main drivers for microgravity simulation-induced immune-physiological changes: findings from the VIVALDI studies

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月16日

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  • Dominique Moser,
  • Marie-Pierre Bareille,
  • Angelique van Ombergen,
  • Marion Hoerl,
  • Federico D´Amico,
  • Matthias Feuerecker,
  • Christopher Dächert,
  • Sandra Matzel,
  • Adrien Robin,
  • Nastassia Navasiolava,
  • Marc-Antoine Custaud,
  • Alexander Choukér,
  • A. Robin,
  • M.-A. Custaud,
  • N. Navasiolava,
  • C. Laurens,
  • A. Bergouignan,
  • L. Vico,
  • A. Chopard,
  • A. Pav-Le Traon,
  • A. Choukér,
  • D. Moser,
  • D. A. Green,
  • Michael Tipton,
  • P. Denise,
  • H. Normand,
  • S. Blanc,
  • E. Rosnet

摘要

Microgravity strongly affects human physiology during spaceflight. Biological sex has not yet been sufficiently considered as a variable for spaceflight deconditioning. The VivalDI studies investigated physiological systems affected by 5-days dry immersion (DI) in females and males, with a focus on immune changes in this report. In both sexes proportions of peripheral granulocytes and NK cells were elevated during DI and T-cell numbers were reduced. Leukocyte activation and cytokine levels were moderately affected. Females showed a higher Torque-Teno-virus shedding at the end of DI. Noradrenaline concentrations increased during the study with sex-specific patterns. Hemodynamics suggest that immunological changes were caused by DI-induced fluid shifts. Moreover, male study participants’ patterns were compared to a historical data set from a 5-days head-down-tilt bed rest (HDT-BR) study. Changes in leukocyte proportions and body fluid indicators were stronger in DI versus HDT-BR. These analyses indicate that fluid shifts primarily drive intervention-related immune-physiological differences, independent of biological sex. ClinicalTrials.gov, TRN: NCT05043974 and NCT05493176.