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<p>This study evaluates reaction forces and cardiovascular responses during seated lower body negative pressure (LBNP). Ten healthy subjects were exposed to randomized LBNP levels (−10 to −40 mmHg) while seated in a sealed chamber. Gluteal, foot, and total reaction forces, along with heart rate and blood pressure, were measured at each level. Reaction forces increased significantly with rising LBNP (<i>P</i> &lt; 0.05), exceeding baseline at 10 mmHg and doubling by 30 mmHg. Cardiovascular parameters remained stable, indicating no acute hemodynamic risk. Force generation was dependent on LBNP amplitude and waist cross-sectional area. These findings suggest that seated LBNP is a safe and effective method to simulate Earth-like seated posture in microgravity, offering a promising countermeasure to mitigate musculoskeletal deconditioning and support gravitational adaptation during long-duration spaceflight.</p>

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Increasing seated reaction forces with lower body negative pressure

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月14日

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  • Suhas Rao Velichala,
  • Jonathan Kim,
  • Alan R. Hargens

摘要

This study evaluates reaction forces and cardiovascular responses during seated lower body negative pressure (LBNP). Ten healthy subjects were exposed to randomized LBNP levels (−10 to −40 mmHg) while seated in a sealed chamber. Gluteal, foot, and total reaction forces, along with heart rate and blood pressure, were measured at each level. Reaction forces increased significantly with rising LBNP (P < 0.05), exceeding baseline at 10 mmHg and doubling by 30 mmHg. Cardiovascular parameters remained stable, indicating no acute hemodynamic risk. Force generation was dependent on LBNP amplitude and waist cross-sectional area. These findings suggest that seated LBNP is a safe and effective method to simulate Earth-like seated posture in microgravity, offering a promising countermeasure to mitigate musculoskeletal deconditioning and support gravitational adaptation during long-duration spaceflight.