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<p>Polygenic embryo screening (PES) is used to screen embryos for their genetic likelihood of developing complex conditions and traits. We surveyed 152 U.S. reproductive endocrinology and infertility specialists (REIs) on their views of PES. While most respondents (97%) were at least slightly familiar with PES, general approval of PES was low (12%), with the majority expressing disapproval (46%) or uncertainty (42%). A majority (58%) believed risks outweigh benefits, while only 16% felt benefits outweigh risks. Most clinicians (85–77%) were very or extremely concerned about low accuracy, confusion over results, false expectations, and eugenics. Nonetheless, when asked to vote on whether PES should be allowed, 44% would vote to allow it, 45% would vote to disallow it, and 10% would abstain from voting. REIs showed more support for PES when used to screen for physical and psychiatric health conditions (59–55% approving) rather than behavioral or physical traits (7–6% approving).</p>

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Survey of U.S. reproductive medicine clinicians’ attitudes on polygenic embryo screening

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月1日

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  • Rémy A. Furrer,
  • Dorit Barlevy,
  • Aayushi Gandhi,
  • Shai Carmi,
  • Todd Lencz,
  • Stacey Pereira,
  • Gabriel Lázaro-Muñoz

摘要

Polygenic embryo screening (PES) is used to screen embryos for their genetic likelihood of developing complex conditions and traits. We surveyed 152 U.S. reproductive endocrinology and infertility specialists (REIs) on their views of PES. While most respondents (97%) were at least slightly familiar with PES, general approval of PES was low (12%), with the majority expressing disapproval (46%) or uncertainty (42%). A majority (58%) believed risks outweigh benefits, while only 16% felt benefits outweigh risks. Most clinicians (85–77%) were very or extremely concerned about low accuracy, confusion over results, false expectations, and eugenics. Nonetheless, when asked to vote on whether PES should be allowed, 44% would vote to allow it, 45% would vote to disallow it, and 10% would abstain from voting. REIs showed more support for PES when used to screen for physical and psychiatric health conditions (59–55% approving) rather than behavioral or physical traits (7–6% approving).