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<p>This study characterized computed tomography (CT)-derived body composition and tissue morphology in females with non-metastatic breast cancer (BC), both cross-sectionally (<i>n</i> = 56) and longitudinally (<i>n</i> = 38), including comparisons with healthy women and cachexia-prone females with lung cancer. Morphologic changes occurred in the absence of pronounced muscle loss resultant of lean tissue reductions masked by concurrent increases in intra-muscular adipose. Longitudinal analyses suggest divergent phenotypes: non-cachectic patients (63% of BC cohort) demonstrated compositional shifts amid stable muscle quantity, whereas cachectic patients (37%) exhibited wasting of both muscle and adipose quantities alongside remodeling of externally-deposited adipose. Independent of weight, 32 of 38 patients with BC (84%) demonstrated clinically-relevant declines in muscle quantity and/or quality. Findings highlight the discordance between weight loss and underlying tissue dynamics, suggesting that conventional cachexia definitions may under-detect clinically relevant remodeling in early-stage BC. CT-based phenotyping may therefore refine risk stratification to better inform supportive interventions across cancer populations.</p>

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Characterization of body composition dynamics throughout treatment in patients with early-stage breast cancer

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月28日

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  • Lauren E. Rentz,
  • McKinzey K. Dierkes,
  • Beth Vettiyil,
  • Ida Holásková,
  • Emidio E. Pistilli

摘要

This study characterized computed tomography (CT)-derived body composition and tissue morphology in females with non-metastatic breast cancer (BC), both cross-sectionally (n = 56) and longitudinally (n = 38), including comparisons with healthy women and cachexia-prone females with lung cancer. Morphologic changes occurred in the absence of pronounced muscle loss resultant of lean tissue reductions masked by concurrent increases in intra-muscular adipose. Longitudinal analyses suggest divergent phenotypes: non-cachectic patients (63% of BC cohort) demonstrated compositional shifts amid stable muscle quantity, whereas cachectic patients (37%) exhibited wasting of both muscle and adipose quantities alongside remodeling of externally-deposited adipose. Independent of weight, 32 of 38 patients with BC (84%) demonstrated clinically-relevant declines in muscle quantity and/or quality. Findings highlight the discordance between weight loss and underlying tissue dynamics, suggesting that conventional cachexia definitions may under-detect clinically relevant remodeling in early-stage BC. CT-based phenotyping may therefore refine risk stratification to better inform supportive interventions across cancer populations.