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<p>The PREoperative therapy and Supportive Care in EarLy and Locally Advanced breast cancers (PreSCella) study, conducted within Singapore’s SingHealth network, explored how quality of life (QOL) and supportive care needs change over the course of neoadjuvant therapy (NAT) for breast cancer. Using a longitudinal design, data were collected at three points: before NAT (T1), within two months post-surgery (T2), and at the one-year follow-up (T3). Of 241 patients enrolled, 235 were analysed. Overall QOL improved over time, especially emotional well-being. FACT-B scores rose from 113.3 at T1 to 114.3 at T2 and 120.6 at T3 (T1–T3 change: +7.3 points; 95% CI 4.7–9.8; effect size 0.47). Age-specific assessment tools were used. Women under 40 completed three additional surveys—Body Image Scale (BIS), Dyadic Assessment Scale (DAS), and Female Sexual Function Index (FSFI). They reported mild body image distress (BIS: 6.3 at T1 to 7.2 at T3), stable relationships (DAS: 16.5 to 17.0), but notable declines in sexual function (13% at T1, 75% at T2, 57% at T3). Patients over 65 completed tools like the Attitude Scale and prioritised QOL over survival length. Findings underscore the evolving nature of supportive care needs and the value of age-personalised interventions throughout cancer treatment.</p>

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Outcomes of a prospective cohort study of PREoperative therapy and supportive care in early & locally advanced breast cancers—PreSCella study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月28日

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  • Han Yi Lee,
  • Whee Sze Ong,
  • Jasmine Yun Ting Tan,
  • Jun Ma,
  • Zewen Zhang,
  • Si Ying Tan,
  • Grace Meijuan Yang,
  • Irene Teo,
  • Wei Lin Goh,
  • Mabel May Leng Tan,
  • Yoon Sim Yap,
  • Jack Junjie Chan,
  • Ryan Shea Ying Cong Tan,
  • Wu Meng Tan,
  • Elaine Lim,
  • Huren Sivaraj,
  • Sok Yuen Beh,
  • Lay Tin Soh,
  • Wen Yee Chay,
  • Rebecca Dent,
  • Ravindran Kanesvaran,
  • Mabel Wong,
  • Benita Kiat Tee Tan,
  • Fuh Yong Wong,
  • Kiak Mien Veronique Tan,
  • Tira J. Tan

摘要

The PREoperative therapy and Supportive Care in EarLy and Locally Advanced breast cancers (PreSCella) study, conducted within Singapore’s SingHealth network, explored how quality of life (QOL) and supportive care needs change over the course of neoadjuvant therapy (NAT) for breast cancer. Using a longitudinal design, data were collected at three points: before NAT (T1), within two months post-surgery (T2), and at the one-year follow-up (T3). Of 241 patients enrolled, 235 were analysed. Overall QOL improved over time, especially emotional well-being. FACT-B scores rose from 113.3 at T1 to 114.3 at T2 and 120.6 at T3 (T1–T3 change: +7.3 points; 95% CI 4.7–9.8; effect size 0.47). Age-specific assessment tools were used. Women under 40 completed three additional surveys—Body Image Scale (BIS), Dyadic Assessment Scale (DAS), and Female Sexual Function Index (FSFI). They reported mild body image distress (BIS: 6.3 at T1 to 7.2 at T3), stable relationships (DAS: 16.5 to 17.0), but notable declines in sexual function (13% at T1, 75% at T2, 57% at T3). Patients over 65 completed tools like the Attitude Scale and prioritised QOL over survival length. Findings underscore the evolving nature of supportive care needs and the value of age-personalised interventions throughout cancer treatment.