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<p>Mechanisms linking exercise to reduced breast cancer risk are poorly understood. 103 healthy women, 18–75, were randomized to 45-minutes of acute exercise at 60% VO<sub>2</sub>max (<i>N</i> = 54, intervention), or 45-minutes of rest (<i>N</i> = 49, control). Blood samples were collected at baseline, 45- and 105-minutes, analytes measured by immunoassay, and mean changes from baseline to 45- and 105-minutes modelled using generalized estimating equations, adjusted for confounders. Mean percent changes levels (Δ%) increased in exercisers vs. controls for <i>monocyte chemoattractant protein (MCP)-1</i> Δ<sup>45 min</sup> + 17.1% (<i>P</i> &lt; 0.0001), Δ<sup>105 min</sup> + 12.0% (<i>P</i> = 0.005); <i>interleukin(IL)-6</i>, Δ<sup>45 min</sup> + 103.5%, Δ<sup>105 min</sup> + 92.3%; and at 45-minutes for <i>glucose</i> Δ<sup>45 min</sup> + 8.8%; <i>insulin</i> Δ<sup>45 min</sup> + 82.4% (all <i>P</i> &lt; 0.0001). Differences between arms for <i>vascular endothelial growth factor (VEGF)</i> Δ<sup>45 min</sup> + 9.8%; <i>c-reactive protein</i> Δ<sup>45 min</sup>-6.6%; <i>irisin</i> Δ<sup>45 min</sup>-5.1%; or <i>plasminogen activator inhibitor (PAI)-1</i>, Δ<sup>45 min</sup>-3.6% were non-statistically significant, with similar results at 105-minutes. Results suggest that acute exercise has specific effects on circulating metabolic and inflammatory biomarkers, implicated in breast cancer etiology, which differ from weight-loss-induced changes. Trial registration: Clincialtrials.gov identifier NCT03779867.</p>

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Effects of acute exercise on inflammatory and metabolic biomarkers in women: a randomized controlled trial

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月7日

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  • Catherine Duggan,
  • Jean de Dieu Tapsoba,
  • Jude Warner,
  • Atreya Dash,
  • Ching-Yun Wang,
  • Anne McTiernan

摘要

Mechanisms linking exercise to reduced breast cancer risk are poorly understood. 103 healthy women, 18–75, were randomized to 45-minutes of acute exercise at 60% VO2max (N = 54, intervention), or 45-minutes of rest (N = 49, control). Blood samples were collected at baseline, 45- and 105-minutes, analytes measured by immunoassay, and mean changes from baseline to 45- and 105-minutes modelled using generalized estimating equations, adjusted for confounders. Mean percent changes levels (Δ%) increased in exercisers vs. controls for monocyte chemoattractant protein (MCP)-1 Δ45 min + 17.1% (P < 0.0001), Δ105 min + 12.0% (P = 0.005); interleukin(IL)-6, Δ45 min + 103.5%, Δ105 min + 92.3%; and at 45-minutes for glucose Δ45 min + 8.8%; insulin Δ45 min + 82.4% (all P < 0.0001). Differences between arms for vascular endothelial growth factor (VEGF) Δ45 min + 9.8%; c-reactive protein Δ45 min-6.6%; irisin Δ45 min-5.1%; or plasminogen activator inhibitor (PAI)-1, Δ45 min-3.6% were non-statistically significant, with similar results at 105-minutes. Results suggest that acute exercise has specific effects on circulating metabolic and inflammatory biomarkers, implicated in breast cancer etiology, which differ from weight-loss-induced changes. Trial registration: Clincialtrials.gov identifier NCT03779867.