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<p>The influence of young age at diagnosis on prognosis of patients with metastatic breast cancer (MBC) remains unclear. We examined overall survival (OS) within a single-institution prospective study of patients with de novo or recurrent MBC. Kaplan-Meier curves assessed OS by age (≤35 or ≤40 years as the youngest category) and inferred metastatic tumor subtype. Multivariable Cox regression models estimated hazard ratios (HRs) and 95% CIs for OS by age adjusting for clinical factors. Of 4189 women &lt;75 years, 571 were ≤40 years at MBC diagnosis, of whom 260 were ≤35 years. Over half (52%) died during follow-up (median = 5.3 years, IQR = 2.1–9.8 years). Compared to patients 45–55 years, those ≤35 years at diagnosis experienced worse OS (HR = 1.22, 95%CI 1.00–1.48, <i>p</i> = 0.05). This association was driven by HER2-negative/luminal B-like and hormone receptor-positive/HER2-positive tumors. These findings highlight the need to develop more effective therapies for young patients with this metastatic subtype.</p>

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The association between young age at metastatic breast cancer diagnosis and overall survival in the EMBRACE study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月29日

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  • Kristen D. Brantley,
  • Gregory J. Kirkner,
  • Melissa E. Hughes,
  • Leticia Varella,
  • Georgia Suggs,
  • Olivia M. Cunningham,
  • Sanjana Ravikumar,
  • Craig Snow,
  • Sara M. Tolaney,
  • Sarah Sammons,
  • Ann H. Partridge,
  • Nancy U. Lin

摘要

The influence of young age at diagnosis on prognosis of patients with metastatic breast cancer (MBC) remains unclear. We examined overall survival (OS) within a single-institution prospective study of patients with de novo or recurrent MBC. Kaplan-Meier curves assessed OS by age (≤35 or ≤40 years as the youngest category) and inferred metastatic tumor subtype. Multivariable Cox regression models estimated hazard ratios (HRs) and 95% CIs for OS by age adjusting for clinical factors. Of 4189 women <75 years, 571 were ≤40 years at MBC diagnosis, of whom 260 were ≤35 years. Over half (52%) died during follow-up (median = 5.3 years, IQR = 2.1–9.8 years). Compared to patients 45–55 years, those ≤35 years at diagnosis experienced worse OS (HR = 1.22, 95%CI 1.00–1.48, p = 0.05). This association was driven by HER2-negative/luminal B-like and hormone receptor-positive/HER2-positive tumors. These findings highlight the need to develop more effective therapies for young patients with this metastatic subtype.