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<p>We compared T cell subpopulations in primary invasive breast tumors from Black and White women and investigated breast cancer subtype-specific associations of T cell abundance with survival in Black women. Multispectral immune staining was used to quantify helper, cytotoxic, and regulatory T cells in the tumor and stromal compartments of breast tissues. In fully adjusted models, breast tumors from Black women were significantly more likely than those from White women to have a higher abundance of cytotoxic T cells (IRR, 2.41; 95% CI, 1.43–4.05) and helper T cells (IRR, 1.80; 95% CI, 1.06–3.06), and these differences were more pronounced in the tumor than the stromal compartment. Among Black women, higher levels of T cells were associated with improved survival in women with triple-negative breast cancer, whereas a trend of poorer survival was observed in women with HER2-positive tumors. This study contributes to an accumulating body of evidence that the tumor-immune landscape differs between Black and White women.</p>

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Quantitative analysis of T cell subsets in a population of Black women with invasive breast cancer

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月1日

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  • Angela R. Omilian,
  • Lucas Mendicino,
  • Anthony George,
  • Tina Darabnoushtehrani,
  • Rochelle Payne Ondracek,
  • Wiam Bshara,
  • Chi-Chen Hong,
  • Bo Qin,
  • Elisa V. Bandera,
  • Thaer Khoury,
  • Rikki Cannioto,
  • Song Yao,
  • Christine B. Ambrosone

摘要

We compared T cell subpopulations in primary invasive breast tumors from Black and White women and investigated breast cancer subtype-specific associations of T cell abundance with survival in Black women. Multispectral immune staining was used to quantify helper, cytotoxic, and regulatory T cells in the tumor and stromal compartments of breast tissues. In fully adjusted models, breast tumors from Black women were significantly more likely than those from White women to have a higher abundance of cytotoxic T cells (IRR, 2.41; 95% CI, 1.43–4.05) and helper T cells (IRR, 1.80; 95% CI, 1.06–3.06), and these differences were more pronounced in the tumor than the stromal compartment. Among Black women, higher levels of T cells were associated with improved survival in women with triple-negative breast cancer, whereas a trend of poorer survival was observed in women with HER2-positive tumors. This study contributes to an accumulating body of evidence that the tumor-immune landscape differs between Black and White women.