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<p>We conducted a retrospective analysis of 213 patients with HER2+ T1micN0 breast cancer. Patients with ≥5 foci of microinvasion received more aggressive treatment with higher rates of sentinel lymph node biopsy and adjuvant chemotherapy/HER2-targeted therapy (CT/H2TT) than patients with 1–4 foci. We did not detect significant differences in invasive disease-free survival between patients with 1–4 and ≥5 foci, or between patients with ≥5 foci who did and did not receive adjuvant CT/H2TT.</p>

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Treatment patterns and clinical outcomes of patients with HER2-positive T1micN0 breast cancer: a single-center analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月24日

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  • Celine Yeh,
  • Rachel Han,
  • Abha Kulkarni,
  • Charlie White,
  • Yuan Chen,
  • Matthew G. Hanna,
  • Edi Brogi,
  • Andrew D. Seidman

摘要

We conducted a retrospective analysis of 213 patients with HER2+ T1micN0 breast cancer. Patients with ≥5 foci of microinvasion received more aggressive treatment with higher rates of sentinel lymph node biopsy and adjuvant chemotherapy/HER2-targeted therapy (CT/H2TT) than patients with 1–4 foci. We did not detect significant differences in invasive disease-free survival between patients with 1–4 and ≥5 foci, or between patients with ≥5 foci who did and did not receive adjuvant CT/H2TT.