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<p>Current evidence does not support the application of “no-ink-on-tumor” negative margins following breast-conserving surgery (BCS) in breast cancer (BC) patients who have received neoadjuvant systemic treatment (NST). We compared loco-regional free survival (LRFS), disease-free survival (DFS), and overall survival (OS) based on different tumor margin distance thresholds in a cohort of 235 BC patients treated with NST and subsequent BCS between 01/2015 and 12/2019. The 5-year LRFS was 81.6% in patients with “no-ink-on-tumour”, margins and 71.0% in those with positive margins (<i>p</i> = 0.584). Margins &gt;1 mm were associated with superior outcomes, with a 5-year LRFS of 84.0% compared to 69.3% in patients with margins ≤1 mm (<i>p</i> = 0.005). Additionally, margins &gt;1 mm were significantly correlated with longer DFS (<i>p</i> = 0.028) and OS (<i>p</i> = 0.001). These findings suggest that a surgical margin distance &gt;1 mm provides the best LRFS, DFS, and OS outcomes for this group of BC patients.</p>

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Impact of margin distance on recurrence and survival following breast-conserving surgery after neoadjuvant systemic therapy

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月19日

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  • C. Florin Pop,
  • Clémence Ortega,
  • Mathilde Lecomte,
  • Paulus Kristanto,
  • Chirine Khaled,
  • Filip De Neubourg,
  • Antoine Desmet,
  • Evandro De Azambuja,
  • Denis Larsimont,
  • Isabelle Veys

摘要

Current evidence does not support the application of “no-ink-on-tumor” negative margins following breast-conserving surgery (BCS) in breast cancer (BC) patients who have received neoadjuvant systemic treatment (NST). We compared loco-regional free survival (LRFS), disease-free survival (DFS), and overall survival (OS) based on different tumor margin distance thresholds in a cohort of 235 BC patients treated with NST and subsequent BCS between 01/2015 and 12/2019. The 5-year LRFS was 81.6% in patients with “no-ink-on-tumour”, margins and 71.0% in those with positive margins (p = 0.584). Margins >1 mm were associated with superior outcomes, with a 5-year LRFS of 84.0% compared to 69.3% in patients with margins ≤1 mm (p = 0.005). Additionally, margins >1 mm were significantly correlated with longer DFS (p = 0.028) and OS (p = 0.001). These findings suggest that a surgical margin distance >1 mm provides the best LRFS, DFS, and OS outcomes for this group of BC patients.