Scholarlink

<p>We determined triple-negative breast cancer (TNBC) subtypes, genetic ancestry, and immune features in a cohort of self-reported Black females with TNBC diagnosed at or below age 50. Among 104 tumors, 34.6% were basal-like 1 (BL1), 17.3% basal-like 2 (BL2), 9.6% luminal androgen receptor (LAR), 26.9% mesenchymal (M), and 11.5% unsubtyped (UNS). Subtypes resembled those seen in Europeans or East Asians, with less LAR (9.6% vs. 14.6–24.4%) and more UNS (11.5% vs. 0–7.5%). “High” proportion of West African ancestry was associated with more LAR (14.9% vs. 4.9%) and less M (25.5% vs. 34.2%). M demonstrated reduced immune activity and was marginally associated with worse overall survival in a multivariate model including stage, West African ancestry, BMI, and TILs, meriting future research. Our study is the largest to date of TNBC subtypes in young Black females. These results reinforce TNBC subtypes’ application across populations and potential use as a prognostic biomarker.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Population-specific patterns in assessing molecular subtypes of young black females with triple-negative breast cancer

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年3月11日

查看全文
  • Padma Sheila Rajagopal,
  • Sonya Reid,
  • Run Fan,
  • Lindsay Venton,
  • Anne Weidner,
  • Mya L. Roberson,
  • Susan Vadaparampil,
  • Xuefeng Wang,
  • Sean Yoder,
  • Marilin Rosa,
  • Melinda Sanders,
  • Paula Gonzalez-Ericsson,
  • Jibril Hirbo,
  • Jennifer G. Whisenant,
  • Jennifer Pietenpol,
  • Fei Ye,
  • Tuya Pal,
  • Brian D. Lehmann

摘要

We determined triple-negative breast cancer (TNBC) subtypes, genetic ancestry, and immune features in a cohort of self-reported Black females with TNBC diagnosed at or below age 50. Among 104 tumors, 34.6% were basal-like 1 (BL1), 17.3% basal-like 2 (BL2), 9.6% luminal androgen receptor (LAR), 26.9% mesenchymal (M), and 11.5% unsubtyped (UNS). Subtypes resembled those seen in Europeans or East Asians, with less LAR (9.6% vs. 14.6–24.4%) and more UNS (11.5% vs. 0–7.5%). “High” proportion of West African ancestry was associated with more LAR (14.9% vs. 4.9%) and less M (25.5% vs. 34.2%). M demonstrated reduced immune activity and was marginally associated with worse overall survival in a multivariate model including stage, West African ancestry, BMI, and TILs, meriting future research. Our study is the largest to date of TNBC subtypes in young Black females. These results reinforce TNBC subtypes’ application across populations and potential use as a prognostic biomarker.