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<p>Oxygen homeostasis is a key ecological factor shaping microbial composition, epithelial function, and immune balance in the gut. Spatial and developmental oxygen gradients drive the transition from facultative to obligate anaerobes. Gut hypoxia is maintained by epithelial oxygen consumption and microbial metabolism, forming a positive feedback loop that supports barrier integrity and immune homeostasis. Disruption by inflammation, antibiotics, or diet elevates oxygen availability, promoting dysbiosis, pathogen expansion, and disease risk.</p>

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Oxygen homeostasis: new insight of gut microbiota-host interactions

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月23日

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  • Zhipeng Yang,
  • Juan Yang,
  • Jian Peng,
  • Hongkui Wei

摘要

Oxygen homeostasis is a key ecological factor shaping microbial composition, epithelial function, and immune balance in the gut. Spatial and developmental oxygen gradients drive the transition from facultative to obligate anaerobes. Gut hypoxia is maintained by epithelial oxygen consumption and microbial metabolism, forming a positive feedback loop that supports barrier integrity and immune homeostasis. Disruption by inflammation, antibiotics, or diet elevates oxygen availability, promoting dysbiosis, pathogen expansion, and disease risk.