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<p>Methodological inconsistencies hinder the identification of gut keystone bacteria and their functional mechanisms. This work critically compares identification approaches, elucidates their interactions within the microbiota and host, and systematically details targeted dietary interventions. By explicitly linking keystone identification to diet-driven modulation, it provides a practical and precise framework for developing gut health strategies and managing microbiota-related diseases.</p>

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Research advances in the identification of gut keystone bacteria and formulation of suitable dietary intervention strategies for restoring gut homeostasis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月25日

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  • Qiang Meng,
  • Huimin Zhang,
  • Jianming Ye,
  • Ting Liu,
  • Yihua Li,
  • Wei Song,
  • Yane Luo,
  • Tianli Yue

摘要

Methodological inconsistencies hinder the identification of gut keystone bacteria and their functional mechanisms. This work critically compares identification approaches, elucidates their interactions within the microbiota and host, and systematically details targeted dietary interventions. By explicitly linking keystone identification to diet-driven modulation, it provides a practical and precise framework for developing gut health strategies and managing microbiota-related diseases.